Storyline

Ten years after a plague turns most of the world's population into vampires, a critical blood shortage causes panic and gruesome mutations among the reanimated. Edward (Ethan Hawke), a vampire haematologist, tries to develop a blood substitute when he meets Lionel (Willem Dafoe) and Audrey (Claudia Karvan), two fugitive humans who claim to have a possible cure. Edward casts his lot with them, hoping to perfect the cure before it's too late.