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Sir Arthur Conan Doyle's famous consulting detective, Sherlock Holmes (Jonny Lee Miller), continues his modern-day sleuthing with trusty colleague Joan Watson (Lucy Liu) in London as Series 2 begins. Holmes receives a call from Scotland Yard asking for help to locate Sherlock's former colleague Inspector Lestrade (Sean Pertwee) who has gone missing. While working the case, Sherlock is shocked to learn that his estranged brother, Mycroft (Rhys Ifans), has moved into his old digs at 221B Baker Street and wants to mend their relationship. Back in New York City, the CEO of a financial consulting company is poisoned to death, and one of the suspects is a woman (Laura Benanti) from Sherlock's past who previously killed her father with nitroglycerine. As for Capt. Tommy Gregson (Aidan Quinn), his wife, Cheryl (Talia Balsam), is the victim of a home invasion from a masked gunman. During the probe, Gregson reveals a surprising secret about his personal life. Later, Holmes and Watson face their one-time adversary Moriarty (Natalie Dormer) when she is brought in as a consultant on a kidnapping case; and a surprise visit from Mycroft puts a strain on Holmes' relationship with Watson.
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