The player assumes the role of Parker, a worker toiling in mines run by the Ultor Corporation far beneath the surface of Mars. The miners are suffering from inhuman living conditions and a strange, deadly disease called the Plague that is suddenly sweeping through their ranks.

The miners' anger and resentment are ready to boil over, and the player provides the spark that starts a rebellion against Ultor. The player's goal is to stay alive long enough to bring down Ultor and solve the mystery of the Plague.

This journey takes him from gritty subterranean mines to Ultor's pristine science and nanotech labs to the surface of Mars and even onto satellites orbiting high above the planet.