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Leucine, isoleucine and valine, the Branched Chain Amino Acids (BCAA), make up about one-third of muscle protein. Of these, leucine has been the most thoroughly investigated because its oxidation rate is higher than that of isoleucine or valine. Of all nutrients, leucine possesses the most marked anabolic characteristics in acting as a trigger element for the initiation of protein synthesis. Leucine has been indicated as the sole stimulator of protein synthesis. Leucine also seems to have both insulin-dependent and insulin independent mechanisms for promoting protein synthesis. Approximately 3 to 4 g of additional leucine per day is required to promote maximal protein synthesis, and especially in power-trained athletes.